使用账号密码登录
Welcome Back
使用表单注册
Welcome Back
Brief Introduction
CURRICULUM VITAE
EDUCATION (In reverse chronological order from latest to earliest including postdoctoral training)
Degree Year Major Institution Mentor
Postdoc 2011-2013 Genetics Massachusetts General Hospital Gary Ruvkun
& Harvard Medical School
Ph.D. 2006-2011 Biochemistry UT Southwestern Medical Center Qinghua Liu
B.S. 2002-2006 Biochemistry Nanjing University, China
PROFESSIONAL APPOINTMENTS
Year Position Institution
2021.2-present Professor Institute of Molecular Medicine, College of Future Technology, Peking University
2020.12-present Associate Dean College of Future Technology, Peking University
2020.1-present Vice Director Institute of Molecular Medicine, Peking University
2019.8-2021.1 Associate Professor Institute of Molecular Medicine, Peking University
2017-2022 HHMI International/Research Scholar Howard Hughes Medical Institute
2013.12-2019.7 Assistant Professor Institute of Molecular Medicine, Peking University
HORNORS AND AWARDS
Year Honors and Awards
2019 Xplorer Prize
2019 National Science Fund for Distinguished Young Scholars
2019 15th China Young Female Scientist Award
2019 Young Investigator Award, Chinese Society for Cell Biology
2018 “Innovators under 35, CHINA”, MIT Technology Review
2017 HHMI International Research Scholar
2012-2014 Helen Hay Whitney Research Fellowship
2011 Nominata Award, UT Southwestern Medical Center
2010 Stanford Biochemistry Founders’ Award for Doctoral Excellence
FULL LIST OF PUBLICATIONS (# equal contribution, *corresponding author)
Research Article:
1. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications (2020) 11:5959.
2. Shao L#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications (2020) 11:4639.
3. Li M, Zhang C-S, Zong Y, Feng J-W, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu Y-Q, Chen X, Liu Q-F, Wu J, Lin S-Y, Ye Z, Liu Y, Piao H-L, Yu L, Zhou Z, Xie X-S, Hardie G and Lin S-C. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism 30 (2019) 508-524.
4. Gao K, Li Y, Hu S and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792.
5. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology 21 (2019) 319-327.
6. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signaling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.
7. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin Extends C. elegans Lifespan through Lysosomal Pathway. eLife 6 (2017) e31268.
8. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Research 11 (2016) 1182-1196. (cover story)
9. Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S, Liu Y and Dillin A*. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis. Cell 166 (2016) 1553-1563.
10. Liu Y, Samuel B, Breen P, and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508 (2014) 406-410.
11. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q*. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44 (2011) 502-508.
12. Ye X#, Huang N#, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q* and Zhang H*. Structure of C3PO and mechanism of Human RISC activation. Nat. Struct. Mol. Biol. 18 (2011) 650-657.
13. Okamura K, Robine N, Liu Y, Liu Q, and Lai EC*. R2D2 organizes small regulatory RNA pathways in Drosophila. Mol. Cell Biol. 31 (2011) 884-896.
14. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q*. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753
15. Liu X, Park JK, Jiang F, Liu Y, McKearin D, Liu Q*. Dicer-1, but not loquacious, is critical for assembly of miRNA-induced silencing complex. RNA 12 (2007) 2324-9.
Invited Review:
1. Liu Y*. Epigenetic codes of mitochondrial homeostasis. Nature Aging 1 (2021) 153-154.
2. Wang S, Gao K and Liu Y*. UPRmt coordinates immunity to maintain mitochondrial homeostasis and animal fitness. Mitochondrion (2017).
3. Liu Y and Liu Q*. ATM signals miRNA biogenesis through KSRP. Mol. Cell 41 (2011) 367-368
Epigenetic codes modulate mitochondrial stress response
The ability to detect, respond and adapt to mitochondrial stress ensures the development and survival of organisms. Caenorhabditis elegans responds to mitochondrial stress with induction of the mitochondrial unfolded protein response (UPRmt), a surveillance program that monitors mitochondrial function and buffers the mitochondrial folding environment. Activation of UPRmt also rewires the metabolic state, promotes innate immunity and lifespan extension. Our recent work has revealed that histone and DNA modifications play critical roles in modulating UPRmt and UPRmt-mediated innate immunity and longevity. Future genetic or pharmacological treatments to target these pathways may provide therapeutic potential for the treatment of mitochondrial diseases.