使用账号密码登录
Welcome Back
使用表单注册
Welcome Back
1985-1989 Bachelor, Wuhan University, Wuhan, China. Major: Cell Biology
1990-1996 Ph.D, University of Alabama at Birmingham, Cell and Molecular Biology Graduate Program
1997-2000 Postdoctoral Fellow, Section of Immunobiology
Yale University School of Medicine. Advisor: Richard A. Flavell, Ph.D
2000-2004 Assistant Professor, Department of Immunology, University of Washington School of Medicine
2004-2008 Associate Professor (tenured), Department of Immunology.
University of Texas MD Anderson Cancer Center
2008- 2014 Professor (tenured), Department of Immunology, University of Texas MD Anderson Cancer Center
2008-2013 Director, Center for Inflammation and Cancer,MD Anderson Cancer Center
2010- 2014 Olga Keith and Harry Carothers Wiess Distinguished University Chair in Cancer Research,
MD Anderson Cancer Center
2013-2016 Vice Dean, School of Medicine, Tsinghua University
2014-present Director, Institute for Immunology, Tsinghua University
2015-present Vice Director (Tsinghua),
Peking University-Tsinghua University Center for Life Sciences, Beijing, China
2016- 2016 Executive Vice Dean, School of Medicine, Tsinghua University
2016- present Dean, School of Medicine, Tsinghua University
2017 Director, Beijing Key Lab on Immunological Studies on Chronic Diseases
2009 American Association of Immunologists- BD Bioscience Investigator Award
2011 Fellow, American Association for the Advancement of Science
2014, 2015, 2016 Highly Cited Researcher, Thomson Reuters
2016 Keynote speaker, 2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers
2017 Highly Cited Researcher, Clarivate Analytics
2018 Highly Cited Researcher, Clarivate Analytics2018
2018 Keynote speaker, 45th Annual Meeting of Indian Immunology Society- Immunocon 2018
2018 Plenary Lecture, Korean Association of Immunologists International Meeting 2018
2018 Fountain Valley Investigator of Life Sciences (FViL)
2019 BioLegend William E. Paul Award for Excellence in Cytokine Research
Immunology and Inflammation
We are interested in studying the cellular and molecular mechanisms underlying immune tolerance and immune responses and hope that our research will lead to new approaches of modulating the immune system in a variety of immune diseases and cancers.
1. T lymphocyte differentiation and function
2. Cytokine function and signaling in inflammation
3. Immune tolerance and tumor immunity.
1. Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X.,Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen,W., Clevers, H., Tian, Q., Qi, H., Wei, L. and Dong C. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518.
2. Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J. and Dong, C. T helper 17 cells play a critical pathogenic role in lung cancer. (2014) Proceedings of National Academy of Sciences, USA 111:5664-5669.
3. Reynolds, J. M., Lee, Y.-H., Shi, Y., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S.H., Watarai, H. and Dong, C. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. (2015). Immunity. 42:692-703.
4. Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B. S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., Tian, Q., Aifantis, I., Wei, L. and Dong,C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. (2015) Immunity. 42:613-626.
5. Zhang, Y., Nguyen, T., Tang, P., Kennedy, N. J.,Jiao, H., Zhang, M., Reynolds, J. M., Jaeschke A., Martin-Orozco, N., Chung, Y., He, W. M.,Wang, C., Jia, W., Ge, B., Davis, R. J., Flavell, R. A. and Dong, C. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. (2015). Journal of Biological Chemistry. 290:14875-14883.
6. Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. and Dong, C. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.
7. Liu, X., Lu, H., Chen, T., Nallaparaju, K. C., Yan, X., Tanaka, S., Ichiyama, K., Zhang, X., Zhang, L., Wen, X., Tian, Q., Bian, X., Jin, W., Lai, W. and Dong, C. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747.
8. Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., Divanovic, S. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. (2016) PLoS One 11:e0149783.
9. Lee, J. B., Chen, C. Y., Liu, B., Mugge, L., Angkasekwinai, P., Facchinetti, V., Dong, C., Liu, Y. J., Rothenberg, M. E., Hogan, S. P., Finkelman, F. D., Wang, Y. H. IL-25 and CD4+ TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. (2016) Journal of Allergy and Clinical Immunology. 137:1216-1225.
10. Ichiyama, K., Gonzalez-Martin, A., Kim, B.-S., Jin, H. Y., Jin, W., Xu, W., Sabouri-Ghomi, M., Xu, S., Zheng, P., Xiao, C. and Dong, C. The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression. (2016) Immunity. 44: 1284–1298.
11. Huang, J., Meng, S., Hong, S., Lin, X., Jin, W. and Dong, C. IL-17C is required for lethal inflammation during systemic fungal infection. (2016) Cell and Molecular Immunology. 13: 474-483.
12. Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P., Lu, N. Z.. BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis. (2016) Allergy. 71:640-650.
13. Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. and Dong, C. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.
14. Sandal, I., Karydis, A., Luo, J., Prislovsky, A., Whittington, K. B., Rosloniec, E. F., Dong, C., Novack, D. V., Mydel, P., Zheng, S. G., Radic, M. Z. and Brand, D. D. Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis. (2016) Arthritis Research and Therapy. 18:249.
15. Huang, J., Yuan, Q., Zhu, H., Yin, L., Hong, S., Dong, Z., Jin, W. and Dong, C. Interleukin-17C/IL-17RE augments T cell function in autoimmune hepatitis. (2017) Journal of Immunology. 198:669-680.
16. Maturu, P., Jones, D., Ruteshouser, E. C., Hu, Q., Reynolds, J. M., Hicks, J., Putluri, N., Ekmekcioglu, S., Grimm, E. A., Dong, C. and Overwijk, W. W. Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor. (2017) Neoplasia. 19:237-249.
17. Jiang, Z., Chen,J., Du, X., Cheng,H., Wang, X. and Dong, C. IL-25 blockade inhibits metastasis in breast cancer. (2017) Protein and Cell. 8:191-201.
18. Zhao, X., Guo, Y., Jiang, C., Chang, Q., Zhang, S., Luo, T., Zhang, B., Jia, X., Hung, M. C., Dong, C. and Lin, X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. (2017) Nature Medicine.23:337-346.
19. Wang, A., Ding, X., Demarque, M., Liu, X., Pan, D., Xin, H., Zhong, B., Wang, X., Dejean, A., Jin, W. and Dong, C. Ubc9 is required for positive selection and late-stage maturation of thymocytes. (2017) Journal of Immunology.198:3461-3470.
20. Lee, Y., Martin-Orozco, N., Zheng, P., Li, J., Zhang, P., Tan, H., Park, H. J., Jeong, M., Chang, S. H., Kim, B.-S., Xiong, W., Zang, W., Guo, L., Liu, Y., Dong, Z., Overwijk, W. W., Hwu, P., Yi, Q, Kwak, L., Yang, Z., Mak, T. W., Radvanyi, L. G., Li, W., Ni, L., Liu, D. and Dong, C. Inhibition of B7-H3 checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. (2017) Cell Research. 1034-1045.
21. Edelblum, K. L., Sharon, G., Singh, G., Odenwald, M. A., Sailer, A., Cao, S., Ravens, S., Thomsen, I., El Bissati, K., McLeod, R., Dong, C., Gurbuxani, S., Prinz, I., Mazmanian, S. K. and Turner, J. R. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. (2017) Cellular and Molecular Gastroenterology and Hepatology 4:285-297.
22. Xu, T, Stewart, K. M., Wang, X., Liu, K., Xie, M., Kyu Ryu, J., Li, K., Ma, T., Wang, H., Ni, L., Zhu, S., Cao, N., Zhu, D., Zhang, Y., Akassoglou, K., Dong, C.*, Driggers, E. M.*, Ding, S.* Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. In press. (* co-correspondent authors)
23.Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. In press
24.Jing Li, Younghee, Lee, Yanjian Li, Yu Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan, Zhiying Yang, Michael Q. Zhang, Tak W. Mak, Ling Ni and Chen Dong. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. (2018) Immunity. In press
25.Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong(*). Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825
26. Su Y, Huang J, Zhao X, Lu H, Wang W, Yang XO, Shi Y, Wang X, Lai Y, Dong C. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. (2019) Science immunology 4(36).